University of Wisconsin, USA
The core research area of this laboratory is myelin. Myelin is the insulator of axons and is essential for normal impulse transmission in the nervous system. We are interested in both the development of myelin in the central nervous system (CNS) and how myelin is targeted in acquired disorders of the CNS, in particular in multiple sclerosis (MS). To explore both development and disease of myelin, we use a variety of models, including animals with mutations in myelin genes (the myelin mutants), to study both the genetic control of myelin formation and maintenance and myelin repair. We are especially interested in cells that could be transplanted into the CNS to repair areas of myelin disease.